Cynomolgus M-CSF/CSF-1 (Fc Tag) recombinant protein

Cynomolgus M-CSF/CSF-1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.

C87615; MGC31930; CSF1; M-CSF; RP11-195M16.2; CSF-1; MCSF; CSFM; OP

G7MIF0

Human Cells

A DNA sequence encoding the cynomolgus CSF1 (XP_005542489.1) (Met1-Asn190) was expressed with the Fc region of human IgG1 at the C-terminus. Cynomolgus and Rhesus CSF1 sequences are identical.

Cynomolgus

The recombinant cynomolgus CSF1 consists of 396 amino acids and predicts a molecular mass of 45.1 kDa.

> (15.1+79.5+4.6) % as determined by SDS-PAGE.