Cynomolgus Interferon alpha-B / IFNA8 (Fc Tag) recombinant protein

Cynomolgus Interferon alpha-B / IFNA8 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interferon alpha-B, also known as IFNA8, belongs to the alpha/beta interferon family. Interferons are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumorcells. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They also allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. Interferons also activate immune cells, such as natural killer cells and macrophages. They increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes. They also increase the ability of uninfected host cells to resist new infection by virus. Certain symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. Produced by macrophages, IFN-alpha have antiviral activities.

Interferon alpha-8

INTERFERON ALPHA-8; IFN-ALPHAB; ALPHA 8; IFNA8; IFA8; INTERFERON ALPHA-B'; INTERFERON; IFNA8/6; IFN-ALPHA-8; INTERFERON ALPHA TYPE 201; GENE 8; INTERFERON ALPHA-B2; IFA6; RP11-354P17.14-001; LEIF B; INTERFERON ALPHA FAMILY; INTERFERON ALPHA-B

G7PS89

EGM_06963

Human Cells

A DNA sequence encoding the cynomolgus IFNA8(G7PS89) (Met1-Glu189) was expressed with Fc region of mouse IgG at the C-terminus.

cynomolgus

The recombinant cynomolgus IFNA8 is a disulfide-linked homodimer. The reduced monomer comprises 400 amino acids and has a calculated molecular mass of 46 KDa.The apparent molecular mass of the protein is approximately 48 KDa respectively in SDS-PAGE.

> 95 % as determined by SDS-PAGE

Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitisvirus (VSV).
The ED₅₀ for this effect is typically 0.1-0.6 ng/mL.