Cynomolgus IL-1 beta recombinant protein

Cynomolgus IL-1 beta recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).

IL1B; IL1-BETA; IL-1BETA; IL-1B; IL1F2; IL-1 BETA; IL-1

E. coli

A DNA sequence encoding the mature form of Cynomolgus (Macaca fascicularis) IL1B (Ala 117-Ser 269) was expressed and purified, with an initial Met.

Cynomolgus

The recombinant Cynomolgus IL1B consists of 154 amino acids and has a calculated molecular mass of 17.5 kDa. It migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE

Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells.
The ED₅₀ for this effect is typically 3-15 pg/mL.