Cynomolgus CD200R1 (His Tag) recombinant protein

Cynomolgus CD200R1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cell surface glycoprotein CD200 receptor 1 (CD200R1) is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 is a receptor for the OX-2 membrane glycoprotein. The receptor-substrate interaction may serve as a myeloid downregulatory signal.

OX2R; MOX2R; CD200R; CD200R1; HCRTR2

Human Cells

A DNA sequence encoding the extracellular domain of Cynomolgus (Macaca fascicularis) CD200R (Met 1-Leu 244) precursor was expressed.

Cynomolgus

The recombinant cynomolgus CD200R consists of 232 amino acids and has a calculated molecular mass of 26 kDa. The apparent molecular mass of the recombinant protein is approximately 40-50 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 98 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CD200R at 2 μg/ml (100 μl/well) can bind human CD200 with a linear ranger of 0.3125-5 ng/ml.