Cynomolgus C10ORF54 recombinant protein (C-human IgG1-Fc)

Cynomolgus C10ORF54 recombinant protein (C-human IgG1-Fc)

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C10orf54, also known as GI24, belongs to the immunoglobulin superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.Immune Checkpoint
Immune Checkpoint Detection: ELISA Antibodies
VISTA / GI24 / B7-H5 Immune Checkpoint VISTA / B7-H5 / GI24 Immune Checkpoint Antibodies VISTA / B7-H5 / GI24 Immune Checkpoint Proteins
Immune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy

Platelet receptor Gi24

F7F6S6

Platelet receptor Gi24

Human Cells

A DNA sequence encoding the cynomolgus B7H5 (XP_005565644.1) (Met1-Ala194) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus B7H5 consists of 400 amino acids and predicts a molecular mass of 44.9 kDa.

> 90 % as determined by SDS-PAGE.