Cynomolgus BCA-1 / CXCL13 (His Tag) recombinant protein

Cynomolgus BCA-1 / CXCL13 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. CXCL13 expression may also provide an additional useful tool for the diagnosis of Angioimmunoblastic T-cell lymphoma (AITL).

BCA-1; CXCL13; BCA1; BLR1L; BLC; ANGIE; ANGIE2; SCYB13; 4631412M08RIK

E. coli

A DNA sequence encoding the mature form of Cynomolgus (Macaca fascicularis) CXCL13 (Val 23-Pro 109) was expressed, with an N-terminal polyhistidine tag.

Cynomolgus

The recombinant cynomolgus CXCL13 consists of 103 amino acids and has a calculated molecular mass of 12.4 kDa. The apparent molecular mass of the recombinant protein is approximately 14 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 90 % as determined by SDS-PAGE