Cynomolgus ALK-1 / ACVRL1 (Fc Tag) recombinant protein

Cynomolgus ALK-1 / ACVRL1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

TSR-I; AI115505; ACVRL1; R-3; AI427544; MGC91691; ALK-1; SETHKIR; HHT2; ACVRLK1; HHT; ORW2; ALK1; R3; SKR3

Human Cells

A DNA sequence encoding the cynomolgus ACVRL1 (Met1-Gln118) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus ACVRL1 is a disulfide-linked homodimer. The reduced monomer comprises 338 amino acids and has a calculated molecular mass of 37.8 KDa.The apparent molecular mass of the protein is approximately 53 KDa respectively in SDS-PAGE.

> 90 % as determined by SDS-PAGE

Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3-E1 cells.
The ED₅₀ for this effect is typically 1-5 ng/ml.