CMV Cytomegalovirus Glycoprotein B (Fc Tag)

Cat.#: 504532

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Product Information

  • Product Name
    CMV Cytomegalovirus Glycoprotein B (Fc Tag)
  • Documents
  • Description
    Human cytomegalovirus (CMV) (human herpesvirus 5) glycoprotein B, also referred as CMV gB or gB, which belongs to the herpesviridae glycoprotein B family. It is a 907-amino acid glycoprotein encoded by the ORF of UL55. Cytomegalovirus Glycoprotein B protein is the most abundant component of the envelope, a target of neutralizing antibodies with at least two defined neutralizing epitopes and an essential replication component. Cytomegalovirus Glycoprotein B protein plays important roles in HCMV entry, cell-cell spread of internal virions, and fusion of infected cells. In addition, Cytomegalovirus Glycoprotein B protein is one envelope protein capable of heparin binding. It forms a physical association with host cell annexin II independent of the presence of calcium.
  • Protein short names
    CYTOMEGALOVIRUS GLYCOPROTEIN B; CMV GB; GB
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Lys 700) linked with the cytoplasmic domain (Arg 777-Val 907) of human CMV gB (AAA45920.1, with furin cleavage site mutated from 'RTKR' to 'TTQT') precursor was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    CMV
  • Molecular weight
    The recombinant human CMV glycoprotein B/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 1045 amino acids and has a predicted molecular mass of 118 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of gB/Fc monomer is approximately 160-170 kDa due to glycosylation.
  • Purity
    > 80 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to bind biotinylated Human CD209-Fc (Cat:501551) in functional ELISA.
  • Validations

    CMV Glycoprotein B / gB Protein (Fc Tag) SDS-PAGE

    CMV Glycoprotein B / gB Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"