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Product Name
Mouse NAP-2 / PPBP / CXCL7 (aa 49-109, His Tag) recombinant protein
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Description
Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.
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Protein name
Chemokine (C-X-C motif) ligand 7, isoform CRA_b
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Protein short names
RATTUS NORVEGICUS; THBGB1; BETA-TG; 2400003M24RIK; NEUTROPHIL ACTIVATING PEPTIDE-2; AI854500; CTAPIII; TC1; CTAP3; MDGF; B-TG1; THBGB; TC2; SCYB7; TGB; LA-PF4; TGB1; NAP-2-L1; CHEMOKINE (C-X-C MOTIF) LIGAND 7; CXCL7; CTAP-III; PBP; LDGF; PLATELET BASIC PROTEIN; NAP-2
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Uniprot ID
Q9EQI5
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Gene Name
Ppbp; Cxcl7; mCG_1702
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Ppbp (Q9EQI5) (Ile49-Ile109) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Ppbp consists 80 amino acids and predicts a molecular mass of 9 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Validations
Mouse NAP-2 / PPBP / CXCL7 Protein (aa 49-109, His Tag) SDS-PAGE
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