• CGRRAGGSC peptide

CGRRAGGSC peptide

Not For Human Use, Lab Use Only.

Cat.#: 319308

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Special Price 189.0 USD

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Product Information

  • Product Name
    CGRRAGGSC peptide
  • Documents
  • Sequence
    H-CGRRAGGSC-NH2
  • Three letter code
    H-Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys-NH2
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.98%
  • Molecular Formula
    C30H54N16O10S2
  • Molecular Weight
    862.98
  • Source
    Synthetic
  • Additional Information
    The peptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys)NH2 (denoted as CGRRAGGSC) is an artificially synthesized cyclic nonapeptide that binds to IL-11Rα, as confirmed by phage display technology. Using CGRRAGGSC, imaging and therapeutic analysis based on IL-11Rα expression level have been reported utilizing peptide conjugation with radioactive tracers such as 131I and 153Sm. The specificity of Cy7-CGRRAGGSC in vivo was confirmed by a blocking experiment with unlabelled CGRRAGGSC and an excess of Cy7-CGRRAGGSC using a subcutaneous MCF-7 breast tumor xenograft. Cy7-CGRRAGGSC probe can enable target-specific imaging of tumors expressing IL-11Rα. Therefore, targeting IL-11Rα via optical imaging can be potentially used for the non-invasive and highly sensitive detection and characterization of IL-11Rα-expressing lesions, thus enhancing our ability to assess the effects of therapeutic interventions in the near future.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Li T, Sun J, Hu Y, Yang M, Shi H, Tang L. Near-infrared fluorescent labeled CGRRAGGSC peptides for optical imaging of IL-11Rα in athymic mice bearing tumor xenografts. J Biomed Res. 2019 Nov;33(6):391–7. doi: 10.7555/JBR.33.20180136. PMCID: PMC6891868.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"