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Product Name
Human CADM3/NECL1/IGSF4B (His Tag) recombinant protein
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Description
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
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Protein name
Cell adhesion molecule 3
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Protein short names
SYNCAM3; TSLL1; NECL1; IGSF4B; CADM3; BIGR; NECL-1; FLJ10698; CTA-134P22.1
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Uniprot ID
Q8N126
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Gene Name
CADM3; IGSF4B; NECL1; SYNCAM3; TSLL1; UNQ225/PRO258
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CADM3 isoform 2 (short isoform) (NP_001120645.1) extracellular domain (Met 1-His 330) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CADM3 consists of 317 amino acids and predictes a molecular mass of 35.1 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CADM3 is approximately 39-41 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. Human CADM3 immobilized at 0.8 μg/ml, 100 μl/well will mediate >30% C6 cell adhesion.
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Validations
Human CADM3 / NECL1 / IGSF4B Protein (His Tag) SDS-PAGE
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