Human LFA-3 / CD58 (Fc Tag) recombinant protein

Human LFA-3 / CD58 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

CD58 protein

CD58 MOLECULE; LFA3; SURFACE GLYCOPROTEIN LFA-3; CD58; RP5-1086K13.2; AG3; CD58 ANTIGEN; LFA-3; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3

Q9BRW0

CD58

Human Cells

A DNA sequence encoding the human CD58 (Q9BRW0) (Met1-Arg215) was expressed with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human CD58/Fc is a disulfide-linked homodimer. The reduced monomer comprises 428 amino acids and has a predicted molecular mass of 48.5 kDa. The apparent molecular mass of the protein is approximately 68 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA. Immobilized human CD2-His (Cat:502112) at 10 μg/ml (100 μl/well) can bind human CD58-Fc, The EC₅₀ of human CD58-Fc is 0.04-0.1 μg/ml.
2. Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CD2-His (Cat:502266) at 10 μg/ml (100 μl/well) can bind human CD58-Fc, The EC₅₀ of human CD58-Fc is 0.04-0.10 μg/ml.