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Product Name
Rat CD28 (His Tag) recombinant protein
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Description
CD28Â (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
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Protein name
CD28 antigen
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Protein short names
TP44; MGC138290; CH29-189K17.3; CD28
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Uniprot ID
G3V7C2
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Gene Name
Cd28; rCG_22337
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat Cd28 (EDL98926.1) (Met1-Lys149) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat Cd28 consists 141 amino acids and predicts a molecular mass of 16.4 kDa.
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Purity
> 85 % as determined by SDS-PAGE.
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Validations
Rat CD28 / TP44 Protein (His Tag)
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