• CATH-2 (chicken) peptide

CATH-2 (chicken) peptide

Not For Human Use, Lab Use Only.

Cat.#: 319110

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Optional Service: TFA RemovalWhat's this?

Special Price 220.9 USD

Availability: 3 weeks
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Product Information

  • Product Name
    CATH-2 (chicken) peptide
  • Documents
  • Sequence
    H-RFGRFLRKIRRFRPKVTITIQGSARF-NH2
  • Three letter code
    H-Arg-Phe-Gly-Arg-Phe-Leu-Arg-Lys-Ile-Arg-Arg-Phe-Arg-Pro-Lys-Val-Thr-Ile-Thr-Ile-Gln-Gly-Ser-Ala-Arg-Phe-NH2
  • Length (aa)
    26
  • Peptide Purity (HPLC)
    95.41%
  • Molecular Formula
    C147H245N51O30
  • Molecular Weight
    3206.83
  • Source
    Synthetic
  • Additional Information
    CATH-2 (chicken) is one of four cathelicidins which have been identified in chickens. Cathelicidins constitute a family of host defense peptides (HDPs) and play an important role during the innate immune response and CATH-2 displays strong antimicrobial activities against many different pathogens including gram-positive and gram-negative bacteria and fungi. In addition, CATH-2 has been shown to have immunomodulatory capacities.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Cuperus et al (2013) Avian host defense peptides. Develop. Comp. Immunol. 41(3) 352 PMID: 24583933
    • Ordonez et al (2014) Fungicidal Mechanisms of Cathelicidins LL-37 and CATH-2 Revealed by Live-Cell Imaging. Antimicrob. Agents Chemother. 58(4) 2240 PMID: 24492359
    • Scheenstra et al (2019) Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action. Sci Rep 9 4780 PMID: 30886247
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"