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Product Name
Human CSNK1G2 (His Tag) recombinant protein
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Description
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
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Protein name
Casein kinase I isoform gamma-2
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Protein short names
CK1G2; AI463719; 2810429I12RIK; CSNK1G2
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Uniprot ID
P78368
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Gene Name
CSNK1G2; CK1G2
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human CSNK1G2 (P78368-1) (Met 18-Lys 415) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CSNK1G2 consists of 417 amino acids and predicts a molecular mass of 47.8 kDa. It migrates as an approximately 48 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
The specific activity was determined to be 13 nmol/min/mg using casein as substrate.
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Validations
Human CSNK1G2 Protein (His Tag) SDS-PAGE
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