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Product Name
Human COMP (His Tag) recombinant protein
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Description
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
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Protein name
Cartilage oligomeric matrix protein
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Protein short names
MGC131819; MGC149768; THBS5; EDM1; THROMBOSPONDIN-5; EPD1; TSP5; PSACH; MED; COMP
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Uniprot ID
P49747
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Gene Name
COMP
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human COMP (NP_000086.2) precusor (Met 1-Ala 757) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The mature form of human COMP consists of 748 amino acids after removal of the signal peptide and predicts a molecular mass of 82.4 kDa. As a result of glycosylation, the apparent molecular mass of rhCOMP is approximately 120-130 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human COMP Protein (His Tag) SDS-PAGE
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