Human GALNAC4S-6ST/CHST15 (His Tag) recombinant protein

Human GALNAC4S-6ST/CHST15 (His Tag) recombinant protein

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Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo.

Carbohydrate sulfotransferase 15

GALNAC4S-6ST; 4631426J05RIK; MAD5; MGC34346; KIAA0598; BRAG; RP11-47G11.1; DKFZP781H1369; MKIAA0598; GALNACS-6ST; CHST15

Q7LFX5

CHST15; BRAG; GALNAC4S6ST; KIAA0598

Human Cells

A DNA sequence encoding the human BRAG (NP_056976.2) extracellular domain (Ser 99-Thr 561) was expressed, with a polyhistidine tag at the N-terminus.

Human

The recombinant human BRAG consists of 479 amino acids and predictes a molecular mass of 56 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh BRAG is approximately 70-80 kDa due to glycosylation.

> 97 % as determined by SDS-PAGE