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Product Name
Canine TrkB/NTRK2 (Fc Tag) recombinant protein
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Description
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.
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Protein short names
NTRK2; AI848316; TRK-B; GP145-TRKB/GP95-TRKB; TRKB; TKRB; GP145-TRKB; C030027L06RIK
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the canine NTRK2 (XP_541264.2) (Met1-His430) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Canine
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Molecular weight
The recombinant canine NTRK2 consists 640 amino acids and predicts a molecular mass of 71.2 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Canine TrkB / NTRK2 Protein (Fc Tag) SDS-PAGE
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