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Product Name
Canine NRG1 (His Tag) recombinant protein
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Description
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
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Protein short names
HGL; NDF; HRGA; HRGALPHA; ARIA; 6030402G23RIK; GGF2; D230005F13RIK; HRG1; MSTP131; MST131; GGF; NRG1-IT2; SMDF; GGFII; HRG
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the canine NRG1 (Ser176-Lys240) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Canine
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Molecular weight
The recombinant canine NRG1 consists 84 amino acids and predicts a molecular mass of 9.7 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Canine NRG1 Protein (His Tag)
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