Canine IL18R1 (His Tag) recombinant protein

Canine IL18R1 (His Tag) recombinant protein

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Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

IL18RALPHA; CD218A; IL18RA; IL18R1; IL-1RRP; IL1RRP; CDW218A

Human Cells

A DNA sequence encoding the canine IL18R1 (Met1-Arg327) was expressed with a polyhistidine tag at the C-terminus.

Canine

The recombinant canine IL18R1 consists 320 amino acids and predicts a molecular mass of 37.3 kDa.

> 95 % as determined by SDS-PAGE.