Canine IL18R1 (Fc Tag) recombinant protein

Canine IL18R1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

CDW218A; IL1RRP; IL-1RRP; IL18R1; IL18RA; CD218A; IL18RALPHA

Human Cells

A DNA sequence encoding the canine IL18R1 (XP_854199.2) (Met1-Arg327) was expressed with the Fc region of human IgG1 at the C-terminus.

Canine

The recombinant canine IL18R1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 550 amino acids and has a predicted molecular mass of 62.9 kDa. The apparent molecular mass of the protein is approximately 67-77 kDa in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE