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Product Name
Canine GDNF (Fc Tag) recombinant protein
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Description
Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). It has been found that GFLs play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. As the founding member, GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. It has been shown that GDNF results in two Parkinson's disease clinical trial and in a number of animal trials. It has been taken as a potent survival factor for central motoneurons.
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Protein short names
HFB1-GDNF; ATF1; ATF2; AI385739; ASTROCYTE-DERIVED TROPHIC FACTOR; MGDNF; NEUROTROPHIC FACTOR; HSCR3; ATF; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the canine GDNF (XP_005619436.1) (Arg109-Ile211) was expressed with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Canine
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Molecular weight
The recombinant canine GDNF consists 363 amino acids and predicts a molecular mass of 40 kDa.
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Purity
> (81.3+11.4) % as determined by SDS-PAGE.
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Validations
Canine GDNF Protein (Fc Tag)
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