Canine BCA-1 / CXCL13 (His Tag) recombinant protein

Canine BCA-1 / CXCL13 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. CXCL13 expression may also provide an additional useful tool for the diagnosis of Angioimmunoblastic T-cell lymphoma (AITL).

BCA-1; BCA1; BLR1L; CXCL13; SCYB13; ANGIE2; ANGIE; BLC; 4631412M08RIK

E. coli

A DNA sequence encoding the canine CXCL13 (XP_851619.3) (Val23-Asn110) was expressed with a N-terminal polyhistidine tag.

Canine

The recombinant canine CXCL13 comprises 104 amino acids and has a predicted molecular mass of 12.1 kDa. The apparent molecular mass of the protein is approximately 15 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 95 % as determined by SDS-PAGE