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Product Name
Human PDE4B (His & GST Tag) recombinant protein
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Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
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Protein name
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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Protein short names
DPDE4; RP5-876C12.1; R74983; RP23-57D24.1; PDE4B; PDEIVB; DKFZP686F2182; PDE4B5; MGC126529; DUNCE
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Uniprot ID
Q07343
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Gene Name
PDE4B; DPDE4
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human PDE4B isofrom 2 (NP_001032416.1) (Met 1-Thr 564) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PDE4B/GST chimera consists of 801 amino acids and has a calculated molecular mass of 92.2 kDa. It migrates as an approximately 100 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 80 % as determined by SDS-PAGE
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Validations
Human PDE4B / DPDE4 Protein (His & GST Tag) SDS-PAGE
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