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Human Calsyntenin-1 / CLSTN1 (His Tag) recombinant protein

Cat.#: 502584

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Product Information

  • Product Name
    Human Calsyntenin-1 / CLSTN1 (His Tag) recombinant protein
  • Documents
  • Description
    Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).
  • Protein name
    Calsyntenin-1
  • Protein short names
    CST-1; RP23-422H14.2; ALCALPHA1; 1810034E21RIK; CDHR12; PIK3CD; XB31ALPHA; XB31ALPHA; CST-1; ALC-ALPHA; CSTN1; KIAA0911; RP11-558F24.5; ALCALPHA2
  • Uniprot ID
    O94985
  • Gene Name
    CLSTN1; CS1; KIAA0911
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CLSTN1 (NP_001009566.1) (Met1-Thr859) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CLSTN1 consists 842 amino acids and predicts a molecular mass of 94.4 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human Calsyntenin-1 / CLSTN1 Protein (His Tag)

    Human Calsyntenin-1 / CLSTN1 Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"