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Product Name
Human R-Cadherin / CDH4 (His Tag) recombinant protein
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Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
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Protein name
Cadherin-4
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Protein short names
FLJ40547; MGC126700; RCAD; MGC138355; AW120700; R-CAD; RP23-23G3.1; R-CADHERIN; CDH4; CAD4; R-CADH; FLJ22202
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Uniprot ID
P55283
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Gene Name
CDH4
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of human CAD4 (NP_001785.2) (Met 1-Ala 734) was expressed with a fused polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant pro form of human CAD4 comprises 725 amino acids and predicts a molecular mass of 80 kDa. As a result of glycosylation, rhCAD4 migrates as an approximately 90-100 kDa protein in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Activity
Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. Human CAD4 immobilized at 0.8 μg/ml, 100 μl/well will mediate >20% C6 cell adhesion.
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Validations
Human R-Cadherin / CDH4 Protein (His Tag) SDS-PAGE
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