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Product Name
Human Cadherin-17/LI-cadherin (His Tag) recombinant protein
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Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
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Protein name
Cadherin-17
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Protein short names
HPT1; MGC138218; FLJ26931; HPT-1; RP23-54P14.2; CADHERIN-17; CDH16; LI-CADHERIN; HPT-1/LI; CDH17; MGC142024
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Uniprot ID
Q12864
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Gene Name
CDH17
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CDH17 (Q12864-1) extracellular domain (Met 1-Met 787) was expressed, fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CDH17 consists of 776 amino acids and predictes a molecular mass of 87 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CDH17 is approximately 105-115 kDa due to glycosylation.
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Purity
> 88 % as determined by SDS-PAGE
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Activity
Measured by the ability of the immobilized protein to support the adhesion of MCF-7 human breast adenocarcinoma cells. When 5 x 10E4 cells/well are added to Recombinant Human Cadherin-17 coated plates (5 μg/mL with 100 μL/well), approximately > 30% will adhere after 1 hour at 37℃.
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Validations
Human Cadherin-17 / LI-cadherin / CDH17 Protein (His Tag) SDS-PAGE
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