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Product Name
Human CLEC4N/CLEC4N (Fc Tag) recombinant protein
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Description
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).
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Protein name
C-type lectin domain family 6 member A
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Protein short names
CLEC6A; DECTIN-2]; NKCL; CLECSF10; CLEC4N
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Uniprot ID
Q6EIG7
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Gene Name
CLEC6A; CLECSF10; DECTIN2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human DECTIN2 (NP_001007034) (Thr 42-Leu209) was expressed, fused with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human DECTIN2 /Fc comprises 428 amino acids and has a predicted molecular mass of 47.9 kDa. The apparent molecular mass of the protein is approximately 52 kDa in SDS-PAGE under reducing conditions.
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Purity
> 80 % as determined by SDS-PAGE
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Validations
Human CLEC4N / CLEC6A / Dectin-2 Protein (Fc Tag) SDS-PAGE
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