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Product Name
Mouse CLEC1B/CLEC2 (Fc Tag) recombinant protein
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Description
CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver. It acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
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Protein name
C-type lectin domain family 1 member B
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Protein short names
QDED721; C-TYPE LECTIN DOMAIN FAMILY 1 MEMBER B; UNQ721/PRO1384; CLEC-2; 1810061I13RIK; CLEC2B; PRO1384; C-TYPE LECTIN-LIKE RECEPTOR 2; CLEC2
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Uniprot ID
Q9JL99
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Gene Name
Clec1b; Clec2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Clec1b (NP_064369.1) (Met53-Leu229) was expressed with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Clec1b consists 437 amino acids and predicts a molecular mass of 49.1 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Validations
Clec1b protein SDS-PAGE
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