Human CCL15/MIP-5/MIP-1 delta (aa 46-113, His Tag) recombinant protein

Human CCL15/MIP-5/MIP-1 delta (aa 46-113, His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 15 (CCL15), also known as leukotactin-1, MIP5, MIP1 and HCC-2, is a small cytokine belonging to the C-C chemokine family. CCL15 is prevantly expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung. It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3.

C-C motif chemokine 15

NCC-3; MRP-2B; HMRP-2B; LKN1; SY15; SCYA15; MIP-5; CCL15; NCC3; MIP-1D; MIP-1 DELTA; LKN-1; HCC-2; SCYL3

Q16663

CCL15; MIP5; NCC3; SCYA15

E. coli

A DNA sequence encoding the amino acids (Ser 46 –Ile 113) of human CCL15 (Q16663-1) was expressed, with a polyhistide tag at the C-terminus.

Human

The recombinant human CCL15 (aa 46-113) consists of 79 amino acids and has a calculated molecular mass of 8.9 kDa. It migrates as an approximately 10 KDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE