Human I-309/CCL1/TCA-3 recombinant protein

Human I-309/CCL1/TCA-3 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309/CCL1/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8, and induces biochemical events that may result in the control of chemotaxis, proliferation, apoptosis and adhesion. It has been demonstrated that I-309/CCL1/TCA-3 displays chemotactic activity for monocytes and other cell types such as NK cells and dendritic cells, but not for neutrophils. Furthermore, as the only known physiological ligand for CCR8, I-309/CCL1/TCA-3 was identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection. I-309/CCL1/TCA-3 induce significant levels of LTC4 from elicited eosinophils.

C-C motif chemokine 1

P500; BF534335; SCYA1; I-309; CCL1; TCA-3; RP23-446K18.2; TCA3; SISE

P22362

CCL1; SCYA1

E. coli

A DNA sequence encoding the human CCL1 (P22362) (Lys24-Lys96) was expressed, with a N-terminal Met.

Human

The recombinant human CCL1 consists of 75 amino acids and predicts a molecular mass of 8.7 KDa. It migrates as an approximately 9 KDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE