Budesonide Monoclonal Antibody

Budesonide Monoclonal Antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Product has been tested in direct ELISA.

ELISA

Chemical

Mouse IgG1, κ

Budesonide conjugated with BSA. Protein G affinity purified

Monoclonal

PBS(pH7.4), lyophilized. Reconstitution: Adding sterile water, prepare a stock solution of 2.0 mg/ml.

Store at -20℃. Avoid freeze / thaw cycles.

ELISA: 1:5,000-1:20,000

Budesonide is a potent corticosteroid medication renowned for its efficacy in managing inflammatory diseases affecting both the airways and gastrointestinal tract. This glucocorticoid exerts its therapeutic effects primarily through topical administration, demonstrating a remarkable ability to alleviate symptoms with less impact on the hypothalamic-pituitary-adrenal axis compared to equivalent doses of oral prednisone. Beyond its traditional uses, budesonide has also found application as a payload in antibody–drug conjugates, underscoring its versatility in combating inflammatory conditions and even cancer. By binding to glucocorticoid receptors, budesonide initiates cascades of gene expression changes that modulate inflammation over varying time frames, making it a cornerstone in the treatment of diverse inflammatory disorders.

• Yasir M, Goyal A, Sonthalia S. Corticosteroid Adverse Effects. 2023 Jul 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30285357.
• Gardill BR, Vogl MR, Lin HY, Hammond GL, Muller YA. Corticosteroid-binding globulin: structure-function implications from species differences. PLoS One. 2012;7(12):e52759. doi: 10.1371/journal.pone.0052759. Epub 2012 Dec 26. PMID: 23300763; PMCID: PMC3530532.