Bronchogen peptide

Bronchogen peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-AEDL-OH

H-Ala-Glu-Asp-Leu-OH

4

95.62%

C₁₈H₃₀N₄O₉

446.45

Synthetic

Powder

Designed to support respiratory health, it may have a role in improving lung function and enhancing resistance to respiratory diseases by interacting with specific DNA regions. It is developed to exert tissue-specific effects through gene modulation and interaction with DNA or histones, helping maintain various physiological functions. They are part of a class of bioregulatory peptides studied for their therapeutic potential in anti-aging and disease management​

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Khavinson VKh, Fedoreyeva LI, Vanyushin BF. Site-specific binding of short peptides with DNA modulated eukaryotic endonuclease activity. Bull Exp Biol Med. 2011 May;151(1):66-70. doi: 10.1007/s10517-011-1261-8. PMID: 22442805.

Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.