Bradykinin-potentiating peptide 14a
Not For Human Use, Lab Use Only.
Cat.#: 300354
Special Price 88.6 USD
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Product Name
Bradykinin-potentiating peptide 14a
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Documents
Batch to batch variation of the purity
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Sequence Shortening
Pyroglutamic acid Pyr-WPRPTP-OH
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Sequence
Pyroglutamic acid Pyr-Trp-Pro-Arg-Pro-Thr-Pro-OH
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Length (aa)
7
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Peptide Purity (HPLC)
95.03%
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Molecular Formula
C41H57N11O10
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Molecular Weight
863.95
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Source
Synthetic
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Form
Powder
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Description
Bradykinin-potentiating peptide 14a is a bradykinin-potentiating peptide found in the female venom of Bothrops jararaca, but not in male one's, and is identified by de novo sequencing as cleaved BPP-11a lacking the C-terminal Q-I-P-P sequence.
Bradykinin-potentiating peptide 14a is one of the nineteen different BPPs (bradykinin-potentiating peptides) identified in the venom of B. jararaca. BPPs are short proline-rich oligopeptides that potentiate the activity of bradykinin, leading to an anti-hypertensive effect, with each of them haveeach with varying bradykinin-potentiating activities and inhibition of angiotensin I converting enzyme. They are encoded by a precursor protein in the venom gland of B. jararaca, which consists of seven BPPs aligned in tandem. -
Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Pimenta DC, Prezoto BC, Konno K, et al. Mass spectrometric analysis of the individual variability of Bothrops jararaca venom peptide fraction. Evidence for sex-based variation among the bradykinin-potentiating peptides. Rapid Commun Mass Spectrom. 2007;21(6):1034-42.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"