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  • BMP-2 mimicking oligo peptide

BMP-2 mimicking oligo peptide

Not For Human Use, Lab Use Only.

Cat.#: 319721

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    BMP-2 mimicking oligo peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-SSVPT-NH2
  • Sequence
    H-Ser-Ser-Val-Pro-Thr-NH2
  • Length (aa)
    5
  • Peptide Purity (HPLC)
    95.47%
  • Molecular Formula
    C20H36N6O8
  • Molecular Weight
    488.54
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The BMP-2 mimicking oligopeptide (serine-serine-valine-proline-threonine, SSVPT) is a short peptide sequence designed to replicate the osteoinductive activity of bone morphogenetic protein-2 (BMP-2). This oligopeptide was synthesized using standard Fmoc solid-phase peptide synthesis and was covalently conjugated to the surface of nano-sized hydroxyapatite (HA) via Michael-type addition. The p-HA, or peptide-functionalized nano-HA, served as a reinforcement phase within a poly(methyl methacrylate) (PMMA) cement matrix.

    Incorporation of the SSVPT peptide onto the HA surface aimed to enhance the bioactivity of the composite material. Studies demonstrated that the presence of this BMP-2 mimicking oligopeptide could accelerate the deposition of apatite on the material surface and promote the adhesion and proliferation of human fetal osteoblasts (hFOB). Furthermore, the oligopeptide contributed to increased alkaline phosphatase (ALP) activity in these cells, indicating an enhancement of osteogenic differentiation. The combination of HA and the SSVPT oligopeptide exhibited a synergistic effect on the material's overall bioactivity.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Liu Z, Tang Y, Kang T, Rao M, Li K, Wang Q, Quan C, Zhang C, Jiang Q, Shen H. Synergistic effect of HA and BMP-2 mimicking peptide on the bioactivity of HA/PMMA bone cement. Colloids Surf B Biointerfaces. 2015 Jul 1;131:39-46. doi: 10.1016/j.colsurfb.2015.04.032. Epub 2015 Apr 21. PMID: 25948316.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

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  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"