BMAP-28 peptide
Not For Human Use, Lab Use Only.
Cat.#: 318923
Special Price 180.4 USD
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Product Name
BMAP-28 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-GGLRSLGRKILRAWKKYGPIIVPIIRI-NH2
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Sequence
H-Gly-Gly-Leu-Arg-Ser-Leu-Gly-Arg-Lys-Ile-Leu-Arg-Ala-Trp-Lys-Lys-Tyr-Gly-Pro-Ile-Ile-Val-Pro-Ile-Ile-Arg-Ile-NH2
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Length (aa)
27
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Peptide Purity (HPLC)
95.97%
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Molecular Formula
C145H250N44O29
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Molecular Weight
3073.8
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Source
Synthetic
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Form
Powder
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Description
BMAP-28 (GGLRSLGRKILRAWKKYGPIIVPIIRI-NH2) is a cathelicidin peptide. After implantation of the BMAP-28-coated stent, S. aureus or E. faecalis was inoculated into the bladder. The BMAP-28 coating reduced the bacterial counts for both strains compared to uncoated controls, and this level was further reduced by coadministration of vancomycin intraperitoneally.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Cirioni, O., Giacometti, A., Ghiselli, R., Bergnach, C., Orlando, F., Mocchegiani, F., Silvestri, C., Licci, A., Skerlavaj, B., Zanetti, M., Saba, V., and Scalise, G. (2006) Pre-Treatment of Central Venous Catheters with the Cathelicidin BMAP-28 Enhances the Efficacy of Antistaphylococcal Agents in the Treatment of Experimental Catheter- Related Infection. Peptides 27, 2104-2110.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
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• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"