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  • Big LEN, Mouse peptide

Big LEN, Mouse peptide

Not For Human Use, Lab Use Only.

Cat.#: 317895

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* Buy 1 get 1 free (?) What is TFA?

Special Price 202.40 USD

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Product Information

  • Product Name
    Big LEN, Mouse peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    LENPSPQAPARRLLPP
  • Sequence
    H-Leu-Glu-Asn-Pro-Ser-Pro-Gln-Ala-Pro-Ala-Arg-Arg-Leu-Leu-Pro-Pro-OH
  • Length (aa)
    16
  • Peptide Purity (HPLC)
    96.4%
  • Molecular Formula
    C78H131N25O21
  • Molecular Weight
    1754.98
  • CAS No.
    501036-69-7
  • Source
    Synthetic
  • Form
    Powder
  • Description

    BigLEN is a neuropeptide derived from the proteolytic processing of the precursor protein proSAAS. It is generated from the C-terminal region of proSAAS, along with the neuropeptide PEN, through the actions of enzymes such as PC1/3 and PC2. BigLEN can be further processed into a smaller form known as littleLEN. Studies indicate that BigLEN and PEN exhibit differential subcellular localization; for instance, in certain cell lines, BigLEN localizes to perinuclear regions associated with the Golgi apparatus and immature secretory vesicles, while PEN is found in mature secretory vesicles at cell process tips.

    The neuropeptide BigLEN has been identified as an endogenous ligand for the G protein-coupled receptor GPR171. This receptor is expressed in various brain regions, including the hypothalamus. The BigLEN-GPR171 system is implicated in neural signaling pathways. The anatomical distribution of proSAAS and its derived peptides, such as BigLEN, includes regions like the hypothalamus, hippocampus, and amygdala, suggesting potential roles in neuromodulation within these areas.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Mack SM, Gomes I, Devi LA. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891. doi: 10.1021/acschemneuro.8b00559. Epub 2019 Feb 21. PMID: 30726666; PMCID: PMC6996248.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

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  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"