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  • BHB-Phe peptide

BHB-Phe peptide

Not For Human Use, Lab Use Only.

Cat.#: 319747

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Special Price 199.00 USD

Availability: In Stock
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Product Information

  • Product Name
    BHB-Phe peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    BHB-Phe
  • Sequence
    N-beta-hydroxybutyryl phenylalanine
  • Length (aa)
    1
  • Peptide Purity (HPLC)
    99.32%
  • Molecular Formula
    C13H17NO4
  • Molecular Weight
    251.3
  • Source
    Synthetic
  • Form
    Powder
  • Description
    BHB-Phe, a naturally occurring compound, is key in controlling appetite and body weight. BHB-Phe activates particular neurons in the brain, reducing feeding behaviors in mice, which opens up possibilities for new obesity treatments.

    BHB-Phe acts on the hypothalamus and brainstem during fasting or physical activity, differentiating it from compounds like Lac-Phe. Studies indicate that this pathway may be impaired in individuals with obesity, highlighting the need for further exploration. In the future, BHB-Phe could potentially serve as an innovative and non-restrictive method for weight loss.

    Key Facts

    1. A ketone shunt modifies β-hydroxybutyrate through conjugation with amino acids.

    2. BHB-Phe’s effects on appetite are separate from Lac-Phe, despite similar outcomes.

    3. Administration of BHB-Phe reduces food consumption and body weight in obese mice.

    Link to the related in-stock peptide: Lac-Phe

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Moya-Garzon MD, Wang M, Li VL, et al. A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites. Cell. Published online November 7, 2024. doi:10.1016/j.cell.2024.10.032
    • Li VL, He Y, Contrepois K, et al. An exercise-inducible metabolite that suppresses feeding and obesity. Nature. 2022;606(7915):785-790. doi:10.1038/s41586-022-04828-5
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"