Mouse BACE2 / Beta secretase 2 (His Tag) recombinant protein

Mouse BACE2 / Beta secretase 2 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (By similarity).

Beta-secretase 2

ASP21; BETA-SITE AMYLOID BETA A4 PRECURSOR PROTEIN-CLEAVING ENZYME 2; ASPARTIC-LIKE PROTEASE 56 KDA; ASP 1; ALP56; DRAP; DOWN SYNDROME REGION ASPARTIC PROTEASE; ASPARTYL PROTEASE 1; TRANSMEMBRANE ASPARTIC PROTEINASE ASP1; MEMAPSIN-1; ARP1; BAE2; BETA SECRETASE 2; MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 1; 1110059C24RIK; DOWN REGION ASPARTIC PROTEASE; AI850424; BETA-SECRETASE 2; BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2; 56 KDA ASPARTIC-LIKE PROTEASE; ASP1; CDA13; THETA-SECRETASE; BETA-SITE APP CLEAVING ENZYME 2; AEPLC; CEAP1

Q9JL18

Bace2

Human Cells

A DNA sequence encoding the mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal polyhistidine tag.

Mouse

The recombinant mouse BACE2 comprises 454 amino acids and has a predicted molecular mass of 49.2 kDa. The apparent molecular mass of the protein is approximately 55 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 95 % as determined by SDS-PAGE

Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 (Catalog # ES010).
The specific activity is >50 pmoles/min/μg.