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  • Beta-amyloid (1-40) peptide

Beta-amyloid (1-40) peptide

Not For Human Use, Lab Use Only.

Cat.#: 300214

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* Buy 1 get 1 free (?) What is TFA?

Special Price 506.00 USD

Availability: 5 weeks
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Product Information

  • Product Name
    Beta-amyloid (1-40) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  • Sequence
    Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
  • Length (aa)
    40
  • Peptide Purity (HPLC)
    98%
  • Molecular Formula
    C194H295N53O58S
  • Molecular Weight
    4329.9
  • CAS No.
    131438-79-4
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The Beta-amyloid (1-40) peptide, often abbreviated as Aβ40, is a physiological peptide derived from the amyloid precursor protein (βAPP). It is a major component of senile plaque amyloids and is constitutively present in the brain, cerebrospinal fluid (CSF), and plasma. In its soluble form, Aβ40 exists primarily as a free monomer or in a lipoprotein-bound complex, often associated with apolipoproteins such as apolipoprotein J or E within the high-density lipoprotein cholesterol fraction.

    The concentration of Aβ40 in biological fluids like CSF is dynamically regulated by a balance of synthesis, transport across barriers such as the blood-brain barrier, and degradation by enzymes including insulin-degrading enzyme and neprilysin. Studies indicate that CSF Aβ40 levels exhibit a U-shaped natural course during normal aging, with higher concentrations observed in youth and older age groups, and lower, stable levels during middle adulthood. This age-dependent regulation suggests a correlation with physiological brain remodeling processes.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Shoji M. Cerebrospinal fluid Abeta40 and Abeta42: natural course and clinical usefulness. Front Biosci. 2002 Apr 1;7:d997-1006. doi: 10.2741/A826. PMID: 11897565.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"