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Product Name
Human GRK2 / ADRBK1 (His & GST Tag) recombinant protein
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Description
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
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Protein name
Beta-adrenergic receptor kinase 1
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Protein short names
BARK-1; BETAARK1; ADRBK-1; GRK2; BETA-ARK1; BARK1; BETAARK; FLJ16718; ADRBK1
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Uniprot ID
P25098
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Gene Name
ADRBK1; BARK; BARK1; GRK2
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human ADRBK1 (NP_001610.2) (Met 1-Leu 689) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ADRBK1/GST chimera consists of 926 amino acids and has a calculated molecular mass of 107 kDa. It migrates as an approximately 110 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
No Kinase Activity
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Validations
Human GRK2 / ADRBK1 Protein (His & GST Tag) SDS-PAGE
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