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  • Bacteriocin Leucocin B-TA33a peptide

Bacteriocin Leucocin B-TA33a peptide

Not For Human Use, Lab Use Only.

Cat.#: 315888

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Bacteriocin Leucocin B-TA33a peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    KGKGFWSWASKATSWLTGPQQPGSPLLKKHR
  • Sequence
    H-Lys-Gly-Lys-Gly-Phe-Trp-Ser-Trp-Ala-Ser-Lys-Ala-Thr-Ser-Trp-Leu-Thr-Gly-Pro-Gln-Gln-Pro-Gly-Ser-Pro-Leu-Leu-Lys-Lys-His-Arg-OH
  • Length (aa)
    31
  • Peptide Purity (HPLC)
    95.7%
  • Molecular Formula
    C161H246N46O40
  • Molecular Weight
    3465.9
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Bacteriocin Leucocin B-TA33a is a 31-residue polypeptide produced by Leuconostoc mesenteroides strain TA33a. It belongs to class II bacteriocins, characterized as small, heat-stable, non-lanthionine-containing peptides. Unlike typical class IIa bacteriocins, Leucocin B-TA33a lacks the conserved YGNGV motif and a disulfide bridge. It exhibits a narrow antibacterial spectrum, primarily inhibiting closely related bacteria within the Leuconostoc and Weissella genera.

    Structural studies using circular dichroism reveal that Leucocin B-TA33a adopts a partially amphiphilic α-helical conformation in membrane-mimicking environments, particularly in the presence of anionic surfactants like sodium dodecyl sulfate. This helical propensity, centered around residues 3 to 17, facilitates its adsorption at lipophilic-hydrophilic interfaces. Despite high sequence homology with mesenterocin 52B, Leucocin B-TA33a displays distinct bactericidal kinetics and inhibitory profiles against sensitive strains.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Corbier C, Krier F, Mulliert G, Vitoux B, Revol-Junelles AM. Biological activities and structural properties of the atypical bacteriocins mesenterocin 52b and leucocin b-ta33a. Appl Environ Microbiol. 2001 Apr;67(4):1418-22. doi: 10.1128/AEM.67.4.1418-1422.2001. PMID: 11282585; PMCID: PMC92749.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"