aurB peptide

aurB peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

LVNGGDDVAAAVNTAAQNNADALFVPPP

Leu-Val-Asn-Gly-Gly-Asp-Asp-Val-Ala-Ala-Ala-Val-Asn-Thr-Ala-Ala-Gln-Asn-Asn-Ala-Asp-Ala-Leu-Phe-Val-Pro-Pro-Pro

28

96.2%

C₁₁₈H₁₈₅N₃₃O₄₁

2721.968

Synthetic

Powder

aurB​ is a 28-aa, all-L, unmodified anionic/amphipathic cell-penetrating peptide derived from Chloroflexusauracyanin B (residues 61–88, MW ~2,721 Da). It preferentially enters cancer cells, localizes to mitochondria, and binds the ATP synthase γ subunit (ATP5C/ATP5F1C), inhibiting Complex V–driven ATP production and glycolysis. This triggers caspase-3–dependent, p53/AR‑independent apoptosis, suppresses tumor growth, and synergizes with radiation while reducing lung metastases—all with minimal normal-cell toxicity.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Naffouje SA, Tran DB, Rademacher DJ, Botti V, Christov K, Green A, Li W, Phong NHT, Cannistraro S, Bizzarri AR, Das Gupta TK, Yamada T. Suppression of mitochondrial energy production by a photosynthetic bacterial cupredoxin peptide inhibits tumor growth. Signal Transduct Target Ther. 2026 Apr 7;11(1):124. doi: 10.1038/s41392-026-02703-7. PMID: 41946681; PMCID: PMC13057155.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.