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  • Atrial Natriuretic Factor (1-29) (chicken) peptide

Atrial Natriuretic Factor (1-29) (chicken) peptide

Not For Human Use, Lab Use Only.

Cat.#: 300609

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Product Information

  • Product Name
    Atrial Natriuretic Factor (1-29) (chicken) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    MMRDSGCFGRRIDRIGSLSGMGCNGSRKN
  • Sequence
    H-Met-Met-Arg-Asp-Ser-Gly-Cys-Phe-Gly-Arg-Arg-Ile-Asp-Arg-Ile-Gly-Ser-Leu-Ser-Gly-Met-Gly-Cys-Asn-Gly-Ser-Arg-Lys-Asn-OH (disulfide bond: Cys7-Cys23)
  • Length (aa)
    29
  • Peptide Purity (HPLC)
    96.7%
  • Molecular Formula
    C124H211N47O40S5
  • Molecular Weight
    3160.67
  • Source
    Synthetic
  • Form
    Powder
  • Description

    A novel 29-amino acid natriuretic peptide was identified in chicken heart tissue, purified by monitoring its relaxant effect on chick rectum. The peptide, designated chicken α-ANP (α-chANP), was isolated from both ventricular and atrial extracts and its complete amino acid sequence was determined. The sequence shows remarkable homology with mammalian atrial natriuretic peptide (ANP), particularly within the 17-amino acid ring structure formed by a disulfide linkage, which is essential for biological activity. However, maximum sequence homology was observed between chicken α-ANP and porcine brain natriuretic peptide (BNP), indicating a closer evolutionary relationship to BNP than to mammalian ANP. Unique structural features were noted at the N- and C-terminal regions, including a C-terminal Lys-Asn sequence that differs from the conserved Arg-Tyr found in both mammalian ANP and BNP.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Miyata A, Minamino N, Kangawa K, Matsuo H. Identification of a 29-amino acid natriuretic peptide in chicken heart. Biochem Biophys Res Commun. 1988 Sep 30;155(3):1330-7. doi: 10.1016/s0006-291x(88)81287-7. PMID: 2972278.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

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  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"