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Product Name
Recombinant APOA1 protein (His tag)
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Description
Introducing the recombinant Apolipoprotein A-I (Apo-AI) fragment (residues 94-267), a highly stable and soluble protein unit ideal for structural and biochemical studies. This fragment, derived from human Apo-AI, retains key functional relevance for investigating cholesterol transport mechanisms and related metabolic pathways.
Apolipoprotein A-I (Apo-AI) is a secreted protein crucial for the reverse transport of cholesterol, facilitating efflux from tissues and acting as a cofactor for lecithin cholesterol acyltransferase (LCAT) to promote cholesterol excretion in the liver. It also plays a role in sperm motility activation as part of the SPAP complex. The full-length protein's localization to the secretory pathway underscores its systemic role in lipid metabolism and cardiovascular health.
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Protein name
Apolipoprotein A-I
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Uniprot ID
P02647
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Gene Name
APOA1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 94-267 aa (P02647) were fused with N-terminal 6His tag.
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Sequence
MSKIKHHHHH HGGSEFWDNL EKETEGLRQE MSKDLEEVKA KVQPYLDDFQ KKWQEEMELY RQKVEPLRAE LQEGARQKLH ELQEKLSPLG EEMRDRARAH VDALRTHLAP YSDELRQRLA ARLEALKENG GARLAEYHAK ATEHLSTLSE KAKPALEDLR QGLLPVLESF KVSFLSALEE YTKKLNTQ
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 21.91 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 26 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant APOA1 protein (His tag) SDS-PAGE
M: Marker; Lane 1: APOA1; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"