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  • Apidaecin 5 peptide

Apidaecin 5 peptide

Not For Human Use, Lab Use Only.

Cat.#: 311915

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* Buy 1 get 1 free (?) What is TFA?

Special Price 195.60 USD

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Product Information

  • Product Name
    Apidaecin 5 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    GKPSKPRPAPIKPRPPHPRL
  • Sequence
    H-Gly-Lys-Pro-Ser-Lys-Pro-Arg-Pro-Ala-Pro-Ile-Lys-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-OH
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    97.61%
  • Molecular Formula
    C102H172N34O22
  • Molecular Weight
    2226.67
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Apidaecin 5 is a small, proline-rich peptide antibiotic originally isolated from honeybees (Apis mellifera). It exhibits potent, rapid inhibitory activity against a range of Gram-negative bacteria. Its mechanism of action is distinct from conventional lytic peptides, as it does not rely on membrane permeabilization but instead involves stereoselective recognition of chiral target molecules within bacterial cells.

    Structural analyses of naturally occurring apidaecin-type peptides reveal evolutionarily conserved regions, which are essential for general antibacterial capacity, and variable regions, which confer specificity to the antibacterial spectrum. The peptide's activity is immediate and effective at nanomolar concentrations, though it is inactive against Gram-positive bacteria. The functional delineation into constant and variable regions within such a short peptide sequence is a unique feature, allowing the natural diversity among homologs to target different bacterial strains specifically.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Casteels P, Romagnolo J, Castle M, Casteels-josson K, Erdjument-bromage H, Tempst P. Biodiversity of apidaecin-type peptide antibiotics. Prospects of manipulating the antibacterial spectrum and combating acquired resistance. J Biol Chem. 1994;269(42):26107-15.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"