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Product Name
Anti-TFAP2C / AP2-GAMMA antibody
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Description
Rabbit polyclonal to TFAP2C / AP2-GAMMA
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Tested applications
WB
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Species reactivity
Human TFAP2C / AP2-GAMMA
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Alternative names
Ap-2.2 antibody; AP2gamma antibody; AP2-gamma antibody; AP2-GAMMA antibody; ERF1 antibody; estrogen receptor factor 1 antibody; hAP-2g antibody; RP23-228E2.9 antibody; stimulated by retinoic acid gene 2 antibody; Stra2 antibody; Tcfap2c antibody; TFAP2G antibody; transcription factor AP-2 gamma antibody; transcription factor AP-2 gamma antibody; transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma) antibody; transcription factor ERF-1 antibody; ERF1 antibody; TFAP2G antibody; hAP-2g antibody; AP2-GAMMA antibody; Stra2 antibody; Ap-2.2 antibody; Tcfap2c antibody; AA409384 antibody; AP2gamma antibody; AA409384 antibody; activating enhancer-binding protein 2 gamma antibody; activating enhancer-binding protein 2 gamma antibody
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human TFAP2C / AP2-GAMMA, and purified by antigen affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20 μg/ml
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Validations
TFAP2C / AP2-GAMMA Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2C may be prognostic indicators for patients with breast tumors. TFAP2C gene has been tested for association to diseases (Breast Neoplasms; Carcinoma) and proposed to participate in processes (cell-cell signaling, male gonad development, regulation of transcription from RNA polymerase II promoter). Proteins are expected to have molecular functions (DNA binding, protein binding, protein dimerization activity, transcription factor activity) and to localize in various compartments (membrane, nucleus).
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References
- Woodfield GW, et al. (2009) Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. Clin Cancer Res. 15 (11): 3672-9.
- Zhao C, et al. (2003) Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis. Cancer. 98 (1): 18-23.
- Woodfield GW, et al. (2007) TFAP2C controls hormone response in breast cancer cells through multiple pathways of estrogen signaling. Cancer Res. 67 (18): 8439-43.
- Penna E, et al. (2011) microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. EMBO J. 30 (10): 1990-2007.
- Woodfield GW, et al. (2010) Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes Chromosomes Cancer. 49 (10): 948-62.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"