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Anti-PRIMPOL antibody

Cat.#: 176662

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Special Price 241.9 USD

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Product Information

  • Product Name
    Anti-PRIMPOL antibody
  • Documents
  • Description
    Mouse monoclonal antibody to PRIMPOL
  • Tested applications
    ICC, IHC-P
  • Species reactivity
    Human
  • Alternative names
    MYP22 antibody; CCDC111 antibody; Primpol1 antibody
  • Isotype
    IgG1
  • Preparation
    This antigen of this antibody was recombinant protein
  • Clonality
    Monoclonal
  • Formulation
    Liquid, 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage instructions
    Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Applications

    ICC: 1:100-1:200

    IHC-P: 1:200

  • Validations

    Fig1: ICC staining CCDC111 in HepG2 cells(red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

    Fig1: ICC staining CCDC111 in HepG2 cells(red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

    Fig2: Immunohistochemical analysis of paraffin-embedded human colonic tissue using anti- CCDC111 mouse monoclonal antibody.

    Fig2: Immunohistochemical analysis of paraffin-embedded human colonic tissue using anti- CCDC111 mouse monoclonal antibody.

  • Background
  • References
    • hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. Wan L., Lou J., Xia Y., Su B., Liu T., Cui J., Sun Y., Lou H., Huang J. EMBO Rep. 14:1104-1112(2013)
    • PrimPol, an archaic primase/polymerase operating in human cells. Garcia-Gomez S., Reyes A., Martinez-Jimenez M.I., Chocron E.S., Mouron S., Terrados G., Powell C., Salido E., Mendez J., Holt I.J., Blanco L. Mol. Cell 52:541-553(2013)
    • PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication. Bianchi J., Rudd S.G., Jozwiakowski S.K., Bailey L.J., Soura V., Taylor E., Stevanovic I., Green A.J., Stracker T.H., Lindsay H.D., Doherty A.J. Mol. Cell 52:566-573(2013)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"