Anti-Neuropilin-2/NRP2 antibody

Cat.#: 106482

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Product Information

  • Product Name
    Anti-Neuropilin-2/NRP2 antibody
  • Documents
  • Description
    Mouse monoclonal to Neuropilin-2/NRP2
  • Tested applications
  • Species reactivity
    Human Neuropilin 2 / NRP2
  • Alternative names
    1110048P06Rik antibody; MGC126574 antibody; Neuropilin 2 antibody; Neuropilin 2 antibody; NP2 antibody; Np2 antibody; Npn2 antibody; NPN2 antibody; Npn-2 antibody; Nrp2 antibody; NRP2 antibody; PRO2714 antibody; RP23-149A5.1 antibody; VEGF165R2 antibody; Np-2 antibody
  • Immunogen
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Neuropilin 2 / NRP2 (rh Neuropilin 2 / NRP2; NP_003863.2; Met 1-Tyr 855) and conjugated with PE under optimum conditions, the unreacted PE was removed.
  • Clonality
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.1% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
  • Validations

    Neuropilin 2 / NRP2 Antibody (PE), Mouse MAb, Flow cytometric

    Neuropilin 2 / NRP2 Antibody (PE), Mouse MAb, Flow cytometric

    Profile of anti-NRP2 reactivity on HUVEC cells analyzed by flow cytometry.

  • Background
    Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.
  • References
    • Chen H. et al., 1997, Neuron. 19: 547-59.
    • Bielenberg DR. et al., 2006, Exp Cell Res. 312: 584-93.
    • Yuan L. et al., 2002, Development. 129: 4797-806.
    • Benoit F. et al., 2006, Blood. 108: 1243-50.
    • Sabrina C. et al., 2007, J Biol Chem. 282: 30346-56.
    • Gray MJ. et al., 2008, J Natl Cancer Inst. 100: 109-20.