Anti-NAK/TBK1 Rabbit antibody

Cat.#: 167413

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Product Information

  • Product Name
    Anti-NAK/TBK1 Rabbit antibody
  • Documents
  • Description
    NAK/TBK1 Rabbit polyclonal antibody
  • Tested applications
    WB, ICC/IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    TBK1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human TBK1
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000

    ICC/IF: 1/20

  • Validations

    Western blot detection of NAK/TBK1 in Jurkat,C6,CHO-K1,Hela cell lysates using NAK/TBK1 Rabbit pAb(1:1000 diluted).Predicted band size:84kDa.Observed band size:84kDa.

    Western blot detection of NAK/TBK1 in Jurkat,C6,CHO-K1,Hela cell lysates using NAK/TBK1 Rabbit pAb(1:1000 diluted).Predicted band size:84kDa.Observed band size:84kDa.

  • Background
    Swiss-Prot Acc.Q9UHD2.Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"